OG 488, SE
Chemical Name: 2',7'-Difluoro-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid 2,5-dioxo-1-pyrrolidinyl ester
Biological ActivityGreen fluorescent dye. pH-insensitive in physiological pH range (pKa = 4.6). Can be used to monitor pH change in acidic organelles or pathways. Excitation/emission λ 501/526 nm.
Optical Data for OG 488, SE
|Extinction Coefficient (ε)||76,000 M-1cm-1|
|Quantum Yield (φ)||0.9|
|Closest Laser line||488 nm|
|Reactive Group||NHS ester|
|pH Sensitivity||pH-insensitive in physiological pH range (pKa = 4.6)|
|Correction Factor 280||0.12|
|Application||Imaging, acidic organelle probe, flow, STED|
|Alternative For||TFAX 488, SE, 5(6)-SFX (Fluorescein), SE, FITC,|
Plan Your Experiments
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The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Phagosomal pH determination by dual fluorescence flow cytometry.
Vergene et al.
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