Chemical Name: 1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
Biological ActivityOptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Lipid-independent control of endothelial and neuronal TRPC3 channels by light.
Tiapko et al.
Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions.
Curcic et al.
TRPC-mediated Ca2+ signaling and control of cellular functions.
Curcic et al.
Semin.Cell Dev.Biol., 2019;94:28
An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.
Lichtenegger et al.
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