OptoBI-1

Key Product Details

Product Description

OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC₅₀ for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Product Specifications for OptoBI-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OptoBI-1

The following data is based on the product molecular weight 523.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.10 mL	95.48 mL	190.96 mL
0.5 mM	3.82 mL	19.10 mL	38.19 mL
1 mM	1.91 mL	9.55 mL	19.10 mL
5 mM	0.38 mL	1.91 mL	3.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lichtenegger An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 2018 PMID: 29556099
• Curcic Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 2019 PMID: 30974125
• Curcic TRPC-mediated Ca²⁺ signaling and control of cellular functions. Semin.Cell Dev.Biol. 2019 PMID: 30738858
• Tiapko Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci.

Product Documents for OptoBI-1