OptoBI-1

Catalog # Availability Size / Price Qty
7013/50
7013/10
OptoBI-1 | TRPC Channel Activators
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Description: Photoswitchable TRPC3/6/7 agonist

Chemical Name: 1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one

Purity: ≥98%

Product Details
Reviews

Biological Activity

Photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Technical Data

M.Wt:
523.67
Formula:
C32H37N5O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Lipid-independent control of endothelial and neuronal TRPC3 channels by light.
    Tiapko et al.
    Chem.Sci., 2019;10:2837
  2. Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions.
    Curcic et al.
    Pharmacol.Ther., 2019;200:13
  3. TRPC-mediated Ca2+ signaling and control of cellular functions.
    Curcic et al.
    Semin.Cell Dev.Biol., 2019;94:28
  4. An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.
    Lichtenegger et al.
    Nat.Chem.Biol., 2018;14:396

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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