Oxyntomodulin (porcine, bovine)
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Description: GLP-1 receptor agonist; endogenous preproglucagon derived peptide; modulates feeding and metabolism
Alternative Names: Glucagon (1-37), Enteroglucagon
Purity: ≥95%
Biological Activity
Oxyntomodulin (porcine, bovine) is a GLP-1 receptor agonist. Endogenous preproglucagon-derived neuropeptide that modulates feeding and metabolism. Also secreted by intestinal L-cells. Increases cAMP production and inhibits gastric acid secretion in rat stomach. Also weak glucagon receptor agonist.Technical Data
M.Wt:
4421.86
Formula:
C192H295N59O60S
Sequence:
HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIA
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
62340-29-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
-
Oxyntomodulin (glucagon-37) and its C-terminal octapeptide inhibit gastric acid secretion.
Jarrousse et al.
FEBS Lett., 1985;188:81 -
Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities.
Bataille et al.
Peptides, 1981;2:41 -
A new role for enteric glucagon-37: acute stimulation of glucose absorption in rat small intestine.
Stumpel et al.
FEBS Lett., 1997;410:515 -
Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides.
Vrang and Larsen et al.
Prog.Neurobiol., 2010;92:442
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