Oxyntomodulin (porcine, bovine)
Biological ActivityOxyntomodulin (porcine, bovine) is a GLP-1 receptor agonist. Endogenous preproglucagon-derived neuropeptide that modulates feeding and metabolism. Also secreted by intestinal L-cells. Increases cAMP production and inhibits gastric acid secretion in rat stomach. Also weak glucagon receptor agonist.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Oxyntomodulin (glucagon-37) and its C-terminal octapeptide inhibit gastric acid secretion.
Jarrousse et al.
FEBS Lett., 1985;188:81
Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities.
Bataille et al.
A new role for enteric glucagon-37: acute stimulation of glucose absorption in rat small intestine.
Stumpel et al.
FEBS Lett., 1997;410:515
Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides.
Vrang and Larsen et al.
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