Chemical Name: 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid
Biological ActivityPA 452 is a RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.
Yasmin et al.
Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
Takahashi et al.
Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB.
Nakayama et al.
Citations for PA 452
The citations listed below are publications that use Tocris products. Selected citations for PA 452 include:
2 Citations: Showing 1 - 2
A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection.
Authors: Yuan Et al.
Front Microbiol 2018;9:908
Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Authors: Wang Et al.
J Mol Cell Biol 2017;9:338
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