Catalog Number: 5086
Chemical Name: 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid
Biological Activity
RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.
Technical Data
  • M.Wt:
    439.59
  • Formula:
    C26H37N3O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    457657-34-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.
    Yasmin et al.
    J.Mol.Biol., 2010;397:1121
  2. Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
    Takahashi et al.
    J.Med.Chem., 2002;45:3327
  3. Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB.
    Nakayama et al.
    J.Med.Chem.Lett, 2011;2:896

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