Home / Retinoid X Receptor Antagonists / PA 452

PA 452

Catalog #: 5086
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5086/10
5086/50
PA 452 | CAS No. 457657-34-0 | Retinoid X Receptor Antagonists
1 Image
Description: RXR antagonist

Chemical Name: 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PA 452 is an RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.

Technical Data

M.Wt:
439.59
Formula:
C26H37N3O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
457657-34-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for PA 452

The citations listed below are publications that use Tocris products. Selected citations for PA 452 include:

2 Citations: Showing 1 - 2

  1. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection.
    Authors: Yuan Et al.
    Front Microbiol  2018;9:908
  2. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
    Authors: Wang Et al.
    J Mol Cell Biol  2017;9:338

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