RXR antagonist (pA2
= 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.
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Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.
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Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
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Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB.
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