Catalog Number: 0879
Alternate Names: PEA
Chemical Name: N-(2-Hydroxyethyl)hexadecanamide
Biological Activity
Endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO and to 25 mM in ethanol
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The orphan receptor GPR55 is a novel cannabinoid receptor.
    Ryberg et al.
    Br.J.Pharmacol., 2007;152:1092
  2. Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals.
    Re et al.
    Vet.J., 2005;173:21
  3. Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.
    Lambert et al.
    Epilepsia, 2001;42:321
  4. The palmitoylethanolamide family: a new class of anti-inflammatory agents?
    Lambert et al.
    Curr.Med.Chem., 2002;9:663
  5. The search for the palmitoylethanolamide receptor.
    Lo Verme et al.
    Life Sci., 2005;77:1685
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