Chemical Name: N-(2-Hydroxyethyl)hexadecanamide
Biological ActivityPalmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.
Lambert et al.
The palmitoylethanolamide family: a new class of anti-inflammatory agents?
Lambert et al.
The search for the palmitoylethanolamide receptor.
Lo Verme et al.
Life Sci., 2005;77:1685
Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals.
Re et al.
Citations for Palmitoylethanolamide
The citations listed below are publications that use Tocris products. Selected citations for Palmitoylethanolamide include:
10 Citations: Showing 1 - 10
A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
Sci Rep 2017;7(1):7363
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Authors: Lin Et al.
J Neuroinflammation 2015;16:5555
Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system.
Authors: Raso Et al.
Int J Mol Sci 2015;10:e0123602
Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
Authors: Redlich Et al.
PLoS One 2014;11:108
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
Authors: Scuderi Et al.
Br J Pharmacol 2012;9:49
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors.
Authors: Melis Et al.
J Neurosci 2008;28:13985
'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.
Authors: Ho Et al.
Br J Pharmacol 2008;155:837
Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells.
Authors: Nieri Et al.
Br J Pharmacol 2006;148:682
The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
Authors: Maingret Et al.
EMBO J 2001;20:47
Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries.
Authors: Chataigneau Et al.
Proc Natl Acad Sci U S A 1998;123:968
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