Catalog # Availability Size / Price Qty
Palmitoylethanolamide | CAS No. 544-31-0 | GPR55 Receptor Agonists
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Description: Selective GPR55 agonist. FAAH and PAA substrate
Alternative Names: PEA

Chemical Name: N-(2-Hydroxyethyl)hexadecanamide

Product Details
Citations (10)
Supplemental Products

Biological Activity

Palmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.

Technical Data

Soluble to 20 mM in DMSO and to 25 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Palmitoylethanolamide

The citations listed below are publications that use Tocris products. Selected citations for Palmitoylethanolamide include:

10 Citations: Showing 1 - 10

  1. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
    Authors: Musella
    Sci Rep  2017;7(1):7363
  2. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    J Neuroinflammation  2015;16:5555
  3. Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system.
    Authors: Raso Et al.
    Int J Mol Sci  2015;10:e0123602
  4. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
    Authors: Redlich Et al.
    PLoS One  2014;11:108
  5. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    Br J Pharmacol  2012;9:49
  6. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors.
    Authors: Melis Et al.
    J Neurosci  2008;28:13985
  7. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.
    Authors: Ho Et al.
    Br J Pharmacol  2008;155:837
  8. Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells.
    Authors: Nieri Et al.
    Br J Pharmacol  2006;148:682
  9. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
    Authors: Maingret Et al.
    EMBO J  2001;20:47
  10. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries.
    Authors: Chataigneau Et al.
    Proc Natl Acad Sci U S A  1998;123:968


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