Palmitoylethanolamide

  ( 8 citations )    
Product Datasheet
Catalog Number:0879
Alternate Names:PEA
Chemical Name:N-(2-Hydroxyethyl)hexadecanamide
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.
Technical Data
  • M.Wt:
    299.5
  • Formula:
    C18H37NO2
  • Solubility:
    Soluble to 20 mM in DMSO and to 25 mM in ethanol
  • Storage:
    Store at RT
  • CAS No:
    544-31-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Palmitoylethanolamide include:

8 Citations: Showing 1 - 8
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  1. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
    Authors: Musella
    Sci Rep  2017;7(1):7363
  2. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    J Neuroinflammation  2015;16:5555
  3. Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system.
    Authors: Raso Et al.
    Int J Mol Sci  2015;10:e0123602
  4. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
    Authors: Redlich Et al.
    PLoS One  2014;11:108
  5. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    Br J Pharmacol  2012;9:49
  6. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
    Authors: Melis Et al.
    J Neurosci  2008;28:13985
  7. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.
    Authors: Ho Et al.
    Br J Pharmacol  2008;155:837
  8. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries.
    Authors: Chataigneau Et al.
    Proc Natl Acad Sci U S A  1998;123:968

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