Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Biological ActivityPD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Calpain and calpastatin regulate neutrophil apoptosis.
Squier et al.
J.Cell Physiol., 1999;178:311
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
Wang et al.
Calpains mediate calcium chloride influx during the late phase of cell injury.
Waters et al.
Citations for PD 150606
The citations listed below are publications that use Tocris products. Selected citations for PD 150606 include:
6 Citations: Showing 1 - 6
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
Authors: Chang Et al.
The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability.
Authors: Pradhan Et al.
J Mol Biol 2017;429:192
Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
Int J Cell Biol 2017;2017:1908310
Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons.
Authors: Getz Et al.
Sci Rep 2016;6:31779
ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
Authors: Bill Et al.
PLoS One 2015;6:9173
Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
Authors: Chamma Et al.
J Neurosci 2013;33:15488
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