PD 150606

  ( 5 citations )    
Product Datasheet
Catalog Number:1269
Chemical Name:(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Product Details
Citations (5)
Reviews
Biological Activity
Selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
Technical Data
  • M.Wt:
    306.12
  • Formula:
    C9H7IO2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    179528-45-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 150606 include:

5 Citations: Showing 1 - 5
Filter your results:

  1. The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability.
    Authors: Pradhan Et al.
    J Mol Biol  2017;429:192
  2. Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
    Authors: Alvarez-Arce
    Int J Cell Biol  2017;2017:1908310
  3. Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons.
    Authors: Getz Et al.
    Sci Rep  2016;6:31779
  4. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    PLoS One  2015;6:9173
  5. Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
    Authors: Chamma Et al.
    J Neurosci  2013;33:15488

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used PD 150606?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee