Selective, cell-permeable non-peptide calpain inhibitor (Ki
values for ν
and m-calpains are 0.21 and 0.37 μ
M respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
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All Tocris products are intended for laboratory research use only.
Calpains mediate calcium chloride influx during the late phase of cell injury.
Waters et al.
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
Wang et al.
Calpain and calpastatin regulate neutrophil apoptosis.
Squier et al.
J.Cell Physiol., 1999;178:311
The citations listed below are publications that use Tocris products. Selected citations for PD 150606 include:
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