Catalog Number: 1269
Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Biological Activity
Selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
Technical Data
  • M.Wt:
    306.12
  • Formula:
    C9H7IO2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    179528-45-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Calpains mediate calcium chloride influx during the late phase of cell injury.
    Waters et al.
    J.Pharmacol.Exp.Ther., 1997;283:1177
  2. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
    Wang et al.
    Proc.Natl.Acad.Sci.U.S.A., 1996;93:6687
  3. Calpain and calpastatin regulate neutrophil apoptosis.
    Squier et al.
    J.Cell Physiol., 1999;178:311
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 150606 include:

1 Citations: Showing 1 - 1

  1. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    PLoS One 2015;6:9173

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