A nonpeptide inhibitor of NGF binding to p75NTR
~ 1 μ
M in CHO cells); binds NGF, not p75NTR
. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.
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Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA.
Colquhoun et al.
Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor.
Eibl et al.
Small molecule modulation of p75 neurotrophin receptor functions.
Longo et al.
CNS Neurol.Disord.Drug Targets, 2008;7:63