pep2-SVKI

Name: pep2-SVKI
Brand: Tocris Bioscience
SKU: 1597

Tocris Bioscience | Catalog # 1597

Submit a review

Citations (5)

Product Documents

Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude

Discontinued Product

1597 has been discontinued. View all AMPA Receptor Inhibitors products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude

View all AMPA Receptor Inhibitors »

Product Description

pep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).

Control Peptide also available.

Product Specifications for pep2-SVKI

Molecular Weight

1284.47

Formula

C₆₀H₉₃N₁₃O₁₈

Storage

Desiccate at -20°C

CAS Number

328944-75-8

PubChem ID

90479807

InChI Key

YWTNLHXVGSIPEM-YDSVATBTSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273
Kim Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 2001 PMID: 11573007
Collingridge and Isaac Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 2003 PMID: 12941441

Product Documents for pep2-SVKI

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for pep2-SVKI

For research use only

Citations for pep2-SVKI

Customer Reviews for pep2-SVKI

There are currently no reviews for this product. Be the first to review pep2-SVKI and earn rewards!

Have you used pep2-SVKI?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image