Biological Activitypep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).
Control Peptide also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional roles of protein interactions with AMPA and kainate receptors.
Collingridge and Isaac
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
Daw et al.
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
Kim et al.
AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
Li et al.
Citations for pep2-SVKI
The citations listed below are publications that use Tocris products. Selected citations for pep2-SVKI include:
4 Citations: Showing 1 - 4
Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
Authors: McElligott Et al.
J Neurosci 2010;107:2271
Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
Authors: Grey and Burrell
J Neurophysiol 2010;103:2737
A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
Authors: Dickinson Et al.
Mol Brain 2009;2:18
Activity-dependent synaptic plasticity in retinal ganglion cells.
Authors: Xia Et al.
J Neurosci 2007;27:12221
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