Catalog Number: 1597
Biological Activity
Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Disrupts binding of GluR2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).

Control Peptide also available.

Technical Data
  • M.Wt:
    1284.47
  • Formula:
    C60H93N13O18
  • Sequence:
    YNVYGIESVKI
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    328944-75-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
    Kim et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:11725
  2. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
    Li et al.
    Nat.Neurosci., 1999;2:972
  3. Functional roles of protein interactions with AMPA and kainate receptors.
    Collingridge and Isaac
    Neurosci.Res., 2003;47:3
  4. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
    Daw et al.
    Neuron, 2000;28:873
Citations:

The citations listed below are publications that use Tocris products. Selected citations for pep2-SVKI include:

3 Citations: Showing 1 - 3
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  1. Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
    Authors: McElligott Et al.
    J Neurosci 2010;107:2271
  2. A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
    Authors: Dickinson Et al.
    Mol Brain 2009;2:18
  3. Activity-dependent synaptic plasticity in retinal ganglion cells.
    Authors: Xia Et al.
    J Neurosci 2007;27:12221
Tocris Peptides
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pep2-SVKE

1598 1  
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