Catalog Number: 1597
Biological Activity
Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Disrupts binding of GluR2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). Control peptide available (Cat. No. 1597).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
    Kim et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:11725
  2. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
    Li et al.
    Nat.Neurosci., 1999;2:972
  3. Functional roles of protein interactions with AMPA and kainate receptors.
    Collingridge and Isaac
    Neurosci.Res., 2003;47:3
  4. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
    Daw et al.
    Neuron, 2000;28:873

The citations listed below are publications that use Tocris products. Selected citations for pep2-SVKI include:

Showing Results 1 - 3 of 3

  1. Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
    Authors: McElligott Et al.
    J Neurosci
  2. A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
    Authors: Dickinson Et al.
    Mol Brain
  3. Activity-dependent synaptic plasticity in retinal ganglion cells.
    Authors: Xia Et al.
    J Neurosci
Tocris Peptides
Description Application Cat# Citations Images  


1598 1  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information