Biological ActivityCell-permeable, myristoylated form of pep2m (Cat. No. 1595). Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression.
(Modifications: Lys-1 = N-terminal Myr)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Role of AMPA receptor cycling in synaptic transmission and plasticity.
L?scher et al.
NSF binding to GluR2 regulates synaptic transmission.
Nishimune et al.
Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism.
Noel et al.
Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction.
Luthi et al.
PKMz maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors.
Yao et al.
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