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PF 04991532

Catalog #: 6345 Datasheet / COA / SDS

Discontinued Product

6345 has been discontinued.
View all Glucokinase/GCK products.
PF 04991532 | CAS No. 1215197-37-7 | Glucokinase/GCK
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Description: Potent hepatoselective glucokinase activator

Chemical Name: 6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid

Purity: ≥98%

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Biological Activity

PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.

Technical Data

M.Wt:
396.36
Formula:
C18H19F3N4O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1215197-37-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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