PF 998425

Key Product Details

Product Description

Selective non-steroidal androgen receptor (AR) antagonist (IC₅₀ values are 26 nM and 90 nM in AR binding assays and cellular assays respectively). Displays low affinity for progesterone receptor (IC₅₀ > 10 μM). Active in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 998425

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 998425

The following data is based on the product molecular weight 269.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.57 mL	37.14 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J.Med.Chem. 2008 PMID: 18921992

Product Documents for PF 998425