Chemical Name: 1-(1-Phenylcyclohexyl)piperidine hydrochloride
Biological ActivityPhencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.
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The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine.
Jin et al.
Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression.
Brain Res., 1997;758:51
Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c
Linders et al.
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