Catalog Number: 2557
Alternate Names: PCP
Chemical Name: 1-(1-Phenylcyclohexyl)piperidine hydrochloride
Biological Activity
Non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.
Technical Data
  • M.Wt:
    279.85
  • Formula:
    C17H25N.HCl
  • Solubility:
    Soluble to 40 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    956-90-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c
    Linders et al.
    J.Med.Chem., 1993;36:2499
  2. The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine.
    Jin et al.
    Eur.J.Pharmacol., 1997;319:147
  3. Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression.
    Sharp
    Brain Res., 1997;758:51

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