Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50
= 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β
-islets display enhanced glucose-induced insulin secretion.
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Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27.
Itoh et al.
Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells.
Kato et al.
Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor.
Ma et al.