Catalog Number: 2080
Alternate Names: Peptide histidine methionine 27 (human), Human PHI 27
Biological Activity
Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.
Technical Data
  • M.Wt:
    2985.44
  • Formula:
    C135H214N34O40S
  • Sequence:
    HADGVFTSDFSKLLGQLSAKKYLESLM

    (Modifications: Met-27 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 5% acetonitrile / water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    118025-43-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27.
    Itoh et al.
    Nature, 1983;304:547
  2. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells.
    Kato et al.
    J.Biol.Chem., 1994;269:21223
  3. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor.
    Ma et al.
    Biochem.Pharmacol., 2004;67:1279

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