PHM 27 (human)
Biological ActivityPHM 27 (human) is an endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.
(Modifications: Met-27 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27.
Itoh et al.
Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells.
Kato et al.
Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor.
Ma et al.
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