PHM 27 (human)
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Description: Potent calcitonin agonist; endogenous analog of human VIP
Alternative Names: Peptide histidine methionine 27 (human), Human PHI 27
Biological Activity
Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.Technical Data
M.Wt:
2985.44
Formula:
C135H214N34O40S
Sequence:
HADGVFTSDFSKLLGQLSAKKYLESLM
(Modifications: Met-27 = C-terminal amide)
Solubility:
Soluble to 1 mg/ml in 5% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
87403-73-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27.
Itoh et al.
Nature, 1983;304:547 -
Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells.
Kato et al.
J.Biol.Chem., 1994;269:21223 -
Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor.
Ma et al.
Biochem.Pharmacol., 2004;67:1279
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