PHT 427

Catalog # Availability Size / Price Qty
4598/10
4598/50

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PHT 427 | CAS No. 1191951-57-1 | Akt (Protein Kinase B) Inhibitors
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Description: Dual Akt and PDK1 inhibitor; antitumor

Chemical Name: 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

PHT 427 is a dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Technical Data

M.Wt:
409.61
Formula:
C20H31N3O2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1191951-57-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.
    Moses et al.
    Cancer Res., 2009;69:5073
  2. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
    Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G
    Mol. Cancer Ther., 2010-03-02;9(3):706-17.

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