Catalog Number: 2653
Alternate Names: NSC 303580
Chemical Name: 2-Phenylethynesulfonamide
Biological Activity
Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
Technical Data
  • M.Wt:
    181.21
  • Formula:
    C8H7NO2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    64984-31-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
    Strom et al.
    Nat.Chem.Biol., 2006;2:474
  2. A small molecule inhibitor of inducible heat shock protein 70 (HSP70).
    Leu et al.
    Mol.Cell, 2009;36:15
  3. 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
    Steele et al.
    Blood, 2009;114:1217
  4. Linking the p53 tumor suppressor pathway to somatic cell reprogramming.
    Kawamura et al.
    Nature, 2009;460:1140
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pifithrin-μ include:

4 Citations: Showing 1 - 4
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  1. Blocking Hsp70 Enhances the Efficiency of Amphotericin B Treatment against Resistant Aspergillus terreus Strains.
    Authors: Blatzer Et al.
    Antimicrob Agents Chemother 2015;59:3778
  2. EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro.
    Authors: Xia Et al.
    Biomed Res Int 2014;2014:348728
  3. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    PLoS One 2013;2013:857929
  4. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.
    Authors: Kojima Et al.
    Mol Cancer Ther 2010;9:2545

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