Pifithrin-μ

Catalog # Availability Size / Price Qty
2653/10
2653/50
Cat.No. 2653 - Pifithrin-mu | C8H7NO2S | CAS No. 64984-31-2
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Description: Inhibitor of p53-mitochondrial binding
Alternative Names: NSC 303580

Chemical Name: 2-Phenylethynesulfonamide

Purity: ≥99%

Product Details
Citations (4)
Reviews

Biological Activity

Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Technical Data

M.Wt:
181.21
Formula:
C8H7NO2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
64984-31-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Pifithrin-μ

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