Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ
-radiation in vitro
and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
Strom et al.
A small molecule inhibitor of inducible heat shock protein 70 (HSP70).
Leu et al.
2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
Steele et al.
Linking the p53 tumor suppressor pathway to somatic cell reprogramming.
Kawamura et al.
The citations listed below are publications that use Tocris products. Selected citations for Pifithrin-μ include:
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