Chemical Name: 2-Phenylethynesulfonamide
Biological ActivityPifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
Steele et al.
A small molecule inhibitor of inducible heat shock protein 70 (HSP70).
Leu et al.
Linking the p53 tumor suppressor pathway to somatic cell reprogramming.
Kawamura et al.
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
Strom et al.
Citations for Pifithrin-μ
The citations listed below are publications that use Tocris products. Selected citations for Pifithrin-μ include:
6 Citations: Showing 1 - 6
Cell death mechanisms of the anti-cancer drug EPEG on human cardiomyocytes isolated from pluripotent stem cells.
Authors: Nemade Et al.
Arch Toxicol 2018;92:1507
Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation.
Authors: Li Et al.
Blocking Hsp70 Enhances the Efficiency of amphote. B Treatment against Resistant Aspergillus terreus Strains.
Authors: Blatzer Et al.
Antimicrob Agents Chemother 2015;59:3778
EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro.
Authors: Xia Et al.
Biomed Res Int 2014;2014:348728
Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
Authors: Wang Et al.
PLoS One 2013;2013:857929
The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.
Authors: Kojima Et al.
Mol Cancer Ther 2010;9:2545
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