Pifithrin-μ

Tocris Bioscience | Catalog # 2653

Inhibitor of p53-mitochondrial binding
Tocris Bioscience
Discontinued Product
2653 has been discontinued. View all p53 Inhibitors products.

Key Product Details

Description

Inhibitor of p53-mitochondrial binding

Alternative Names

NSC 303580
View all p53 Inhibitors »

Product Description

Pifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Product Specifications for Pifithrin-μ

Molecular Weight

181.21

Formula

C8H7NO2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Phenylethynesulfonamide

CAS Number

64984-31-2

PubChem ID

327653

InChI Key

ZZUZYEMRHCMVTB-UHFFFAOYSA-N

SMILES

NS(=O)(=O)C#CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.12 100
Ethanol 13.12 100

Preparing Stock Solutions for Pifithrin-μ

The following data is based on the product molecular weight 181.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.52 mL 27.59 mL 55.18 mL
5 mM 1.10 mL 5.52 mL 11.04 mL
10 mM 0.55 mL 2.76 mL 5.52 mL
50 mM 0.11 mL 0.55 mL 1.10 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for Pifithrin-μ

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pifithrin-μ

For research use only

Customer Reviews for Pifithrin-μ (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Pifithrin-μ?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Pifithrin-μ
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: neural cell
    Verified Customer | Posted 07/12/2020
    Pifithrin-µ were dissolved in DMSO and used at a final concentration of 50 µM for pifithrin-µ according to previous studies in which 10-50 µM pifithrin-µ were employed.
    Pifithrin-μ 2653

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All