PNU 22394 hydrochloride

Key Product Details

Product Description

PNU 22394 hydrochloride is a potent 5-HT_2C agonist and partial 5-HT_2A/5-HT_2B agonist. Non-selective between 5-HT₂ receptor subtypes (K_i values are 18, 18 and 66 nM for human recombinant 5-HT_2C, 5-HT_2A and 5-HT_2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.

Product Specifications for PNU 22394 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PNU 22394 hydrochloride

The following data is based on the product molecular weight 236.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jensen Design, synthesis and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem.
• McCall PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Soc.Neurosci.Abstr.

Product Documents for PNU 22394 hydrochloride