PNU 22394 hydrochloride
Chemical Name: 1,2,3,4,5,6-Hexahydro-6-methyl-azepino[4,5-b]indole hydrochloride
Biological ActivityPotent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans.
McCall et al.
Design, synthesis and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
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