Biological ActivityPramlintide is a synthetic version of amylin (Cat. No. 3418). Exhibits high affinity for amylin, CGRP and calcitonin receptors (Ki values are 0.023, 3.8 and 5.1 nM respectively). Reduces postprandial hyperglycemia; also inhibits gastric emptying.
(Modifications: Disulfide bridge: 2-7)
(Modifications: Tyr-37 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pramlintide, the synthetic analogue of amylin: phsyiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk.
Hoogwerf et al.
Vasc.Health Risk Manag., 2008;4:355
Preclinical pharmacology of pramli. in the rat: comparisons with human and rat amylin.
Young et al.
Drug Dev.Res., 1996;37:231
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