Biological ActivityEndogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors. Inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Displays glucose lowering effects in vivo.
(Modifications: Tyr-37 = C-terminal amide, Disulfide bridge between 2 - 7)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Amylin/islet polypeptide: biochemistry, physiology, patho-physiology.
Castillo et al.
Diabete Metab., 1995;21:3
Amylin agonists: a novel approach in the treatment of diabetes.
Schmitz et al.
Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk.
Hoogwerf et al.
Vasc.Health Risk Manag., 2008;4:355
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