Catalog Number: 3710
Alternate Names: APR-246
Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Biological Activity
Methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
Technical Data
  • M.Wt:
    199.25
  • Formula:
    C10H17NO3
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    5291-32-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis.
    Bykov et al.
    Oncogene, 2005;24:3484
  2. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
    Shen et al.
    Oncogene, 2008;27:6571
  3. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
    Stuber et al.
    Mol.Cancer, 2009;8:23
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1MET include:

1 Citations: Showing 1 - 1

  1. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One 2013;8:e78641

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