Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Biological ActivityMethylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
Shen et al.
PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
Stuber et al.
PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis.
Bykov et al.
Citation for PRIMA-1MET
The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1MET include:
1 Citation: Showing 1 - 1
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PRIMA-1MET
There are currently no reviews for this product. Be the first to review PRIMA-1MET and earn rewards!
Have you used PRIMA-1MET?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image