Methylated derivative of PRIMA-1
(Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
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PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis.
Bykov et al.
PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
Shen et al.
PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
Stuber et al.
The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1MET include:
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