PRIMA-1MET
Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Purity: ≥98%
Biological Activity
PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
Shen et al.
Oncogene, 2008;27:6571 -
PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
Stuber et al.
Mol.Cancer, 2009;8:23 -
PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis.
Bykov et al.
Oncogene, 2005;24:3484
Product Datasheets
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Citation for PRIMA-1MET
The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1MET include:
1 Citation: Showing 1 - 1
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RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
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