Chemical Name: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Biological ActivityPRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound.
Bykov et al.
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.
Bykov et al.
PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax.
Wang et al.
Citations for PRIMA-1
The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1 include:
3 Citations: Showing 1 - 3
An inverse docking approach for identifying new potential anti-cancer targets.
Authors: Grinter Et al.
J Neurosci 2011;29:795
Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study.
Authors: Benakanakere Et al.
Endocr Relat Cancer 2009;16:85
Sequential transcription factor targeting for diffuse large B-cell lymphomas.
Authors: Cerchietti Et al.
Cancer Res 2008;68:3361
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