PRIMA-1

  ( 2 citations )    
Product Datasheet
Catalog Number:1862
Chemical Name:2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Product Details
Citations (2)
Reviews
Biological Activity
Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
Technical Data
  • M.Wt:
    185.22
  • Formula:
    C9H15NO3
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    5608-24-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1 include:

2 Citations: Showing 1 - 2
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  1. An inverse docking approach for identifying new potential anti-cancer targets.
    Authors: Grinter Et al.
    J Neurosci  2011;29:795
  2. Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study.
    Authors: Benakanakere Et al.
    Endocr Relat Cancer  2009;16:85

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