Catalog Number: 5191
Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
Biological Activity
Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.
Technical Data
  • M.Wt:
    495.19
  • Formula:
    C17H13Br2N5OS
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    315704-66-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Self-renewal as a therapeutic target in human colorectal cancer.
    Kreso et al.
    Nat.Med., 2014;20:29

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