Pyridostatin pentahydrochloride

Key Product Details

Product Description

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (K_d = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Product Specifications for Pyridostatin pentahydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pyridostatin pentahydrochloride

The following data is based on the product molecular weight 778.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.42 mL	32.09 mL	64.19 mL
1 mM	1.28 mL	6.42 mL	12.84 mL
2 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.13 mL	0.64 mL	1.28 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Müller Small-molecule-mediated G-quadruplex isolation from human cells. Nat.Chem. 2010 PMID: 21107376
• Koirala A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 2011 PMID: 21941250
• Rodriguez Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 20112 PMID: 22306580

Product Documents for Pyridostatin pentahydrochloride