Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd
= 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
Koirala et al.
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Rodriguez et al.
Small-molecule-mediated G-quadruplex isolation from human cells.
M?ller et al.