Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
Biological ActivityBinds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (K d = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Rodriguez et al.
Small-molecule-mediated G-quadruplex isolation from human cells.
M?ller et al.
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
Koirala et al.
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