Catalog Number: 4763
Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
Biological Activity
Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
Technical Data
  • M.Wt:
    778.94
  • Formula:
    C31H32N8O5.5HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
    Koirala et al.
    Nat.Chem., 2011;3:782
  2. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
    Rodriguez et al.
    Nat.Chem.Biol., 20112;8:301
  3. Small-molecule-mediated G-quadruplex isolation from human cells.
    M?ller et al.
    Nat.Chem., 2010;2:1095

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