Catalog Number: 4403
Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamide
Biological Activity
Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
Technical Data
  • M.Wt:
    265.31
  • Formula:
    C13H19N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    382180-17-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
    Butler et al.
    Clin.Cancer Res., 2001;7:962
  2. Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
    Remiszewski et al.
    J.Med.Chem., 2002;45:755
  3. Chemical phylogenetics of histone deacetylases.
    Bradner et al.
    Nat.Chem.Biol., 2010;6:238

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