Pyroxamide

Tocris Bioscience | Catalog # 4403

Histone deacetylase inhibitor
Tocris Bioscience
Discontinued Product
4403 has been discontinued. View all Class I Histone Deacetylases Inhibitors products.

Key Product Details

Description

Histone deacetylase inhibitor
View all Class I Histone Deacetylases Inhibitors »

Product Description

Pyroxamide is an inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Product Specifications for Pyroxamide

Molecular Weight

265.31

Formula

C13H19N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Hydroxy-N'-3-pyridinyloctanediamide

CAS Number

382180-17-8

PubChem ID

4996

InChI Key

PTJGLFIIZFVFJV-UHFFFAOYSA-N

SMILES

O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.53 100

Preparing Stock Solutions for Pyroxamide

The following data is based on the product molecular weight 265.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Pyroxamide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pyroxamide

For research use only

Customer Reviews for Pyroxamide (1)

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  • TGF beta high responder treated with 1.5 μM Pyroxamide (HDAC 1 inhibitor) for 48 h. Cell lysates were analysed by western blot.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: C3-TAg tumour cell
    Verified Customer | Posted 11/15/2019
    TGF beta high responder treated with 1.5 μM Pyroxamide (HDAC 1 inhibitor) for 48 h. Cell lysates were analysed by western blot.
    Pyroxamide 4403

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