Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamide
Biological ActivityInhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Carrillo et al.
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
Butler et al.
Clin.Cancer Res., 2001;7:962
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Remiszewski et al.
Chemical phylogenetics of histone deacetylases.
Bradner et al.
Citation for Pyroxamide
The citations listed below are publications that use Tocris products. Selected citations for Pyroxamide include:
1 Citation: Showing 1 - 1
Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition.
Br J?Cancer 2018;118(10):1359
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