Quinidine
Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Biological Activity
Class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Short QT syndrome genotype-genotype correlations.
Borggrefe et al.
J.Electrocardiol., 2005;38:75 -
Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines.
Caballero et al.
Br.J.Pharmacol., 2003;138:1475 -
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine
Wu et al.
Heart Rhythm., 2008;5:1726
Product Datasheets
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Citations for Quinidine
The citations listed below are publications that use Tocris products. Selected citations for Quinidine include:
2 Citations: Showing 1 - 2
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Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage.
Authors: He Et al.
Glia 2017;65:1251
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Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Authors: Kim Et al.
J Clin Invest 2016;126:4088
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Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.
