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Quinidine

4108 2 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4108/50
Quinidine | CAS No. 56-54-2 | Ion Channel Modulators
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Description: Blocks sodium and potassium channels

Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride

Product Details
Citations (2)
Reviews (2)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Quinidine is a class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Technical Data

M.Wt:
324.42
Formula:
C20H24N2O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store at -20°C
CAS No:
56-54-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Quinidine

The citations listed below are publications that use Tocris products. Selected citations for Quinidine include:

2 Citations: Showing 1 - 2

  1. Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage.
    Authors: He Et al.
    Glia  2017;65:1251
  2. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
    Authors: Kim Et al.
    J Clin Invest  2016;126:4088

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Reviews for Quinidine

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Also a non-competitive alpha-1 adrenoceptor antagonist
By Alex Voisey on 12/15/2020
Application: Species: Rat

Excellent for blocking organic cation transport at 50 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.

Product was used on voltage gated potassium channels Kv11.1 and Kv7.1
By Anonymous on 12/21/2018
Application: Species: Human

Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.

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