Catalog Number: 4108
Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Biological Activity
Class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).
Technical Data
  • M.Wt:
    324.42
  • Formula:
    C20H24N2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    56-54-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines.
    Caballero et al.
    Br.J.Pharmacol., 2003;138:1475
  2. Short QT syndrome genotype-genotype correlations.
    Borggrefe et al.
    J.Electrocardiol., 2005;38:75
  3. Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine.
    Wu et al.
    Heart Rhythm., 2008;5:1726

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