Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Biological ActivityClass IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Short QT syndrome genotype-genotype correlations.
Borggrefe et al.
Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines.
Caballero et al.
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine
Wu et al.
Heart Rhythm., 2008;5:1726
Citations for Quinidine
The citations listed below are publications that use Tocris products. Selected citations for Quinidine include:
2 Citations: Showing 1 - 2
Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage.
Authors: He Et al.
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Authors: Kim Et al.
J Clin Invest 2016;126:4088
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Quinidine
Average Rating: 5 (Based on 2 Reviews)
Have you used Quinidine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Excellent for blocking organic cation transport at 50 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.
Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.