Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Biological ActivityClass IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Short QT syndrome genotype-genotype correlations.
Borggrefe et al.
Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines.
Caballero et al.
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine
Wu et al.
Heart Rhythm., 2008;5:1726
Citations for Quinidine
The citations listed below are publications that use Tocris products. Selected citations for Quinidine include:
2 Citations: Showing 1 - 2
Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage.
Authors: He Et al.
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Authors: Kim Et al.
J Clin Invest 2016;126:4088
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Reviews for Quinidine
Average Rating: 5 (Based on 1 Review)
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Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.