Quinidine

Tocris Bioscience | Catalog # 4108

Blocks sodium and potassium channels
Tocris Bioscience

Key Product Details

Description

Blocks sodium and potassium channels
View all Ion Channel Modulators »

Product Description

Quinidine is a class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Product Specifications for Quinidine

Molecular Weight

324.42

Formula

C20H24N2O2

Storage

Store at -20°C

Chemical Name

(S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride

CAS Number

56-54-2

PubChem ID

3036746

InChI Key

LOUPRKONTZGTKE-LHFMAAMQSA-N

SMILES

O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100
Ethanol 8.11 25

Preparing Stock Solutions for Quinidine

The following data is based on the product molecular weight 324.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for Quinidine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Quinidine

For research use only

Customer Reviews for Quinidine (2)

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  • Also a non-competitive alpha-1 adrenoceptor antagonist
    Name: Alex Voisey
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 12/15/2020
    Excellent for blocking organic cation transport at 50 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.
    Quinidine 4108
  • Product was used on voltage gated potassium channels Kv11.1 and Kv7.1
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/21/2018
    Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.
    Quinidine 4108

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