Catalog Number: 4494
Chemical Name: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile
Biological Activity
Enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in 1eq. NaOH and to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.
    Weiser et al.
    Endocrinology, 2009;150:1817
  2. Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands.
    Carroll et al.
    J.Med.Chem., 2011;55:528

The citations listed below are publications that use Tocris products. Selected citations for (R)-DPN include:

Showing Results 1 - 1 of 1

  1. Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors.
    Authors: Murata Et al.
    Mol Cell Biol
Tocris Small Molecules
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