Catalog Number: 5250
Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Biological Activity
Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK�/AMPK and heme oxygenase-1 activation.
    Tian et al.
    J.Pharmacol.Exp.Ther., 2014;350:5
  2. Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.
    Levitt et al.
    BMC Clin. Pharmacol., 2006;6:1
  3. Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme.
    Stevens et al.
    Comp.Biochem.Physiol C., 1988;91:493
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