Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Biological ActivityRamipril is a non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK�/AMPK and heme oxygenase-1 activation.
Tian et al.
Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme.
Stevens et al.
Comp.Biochem.Physiol C., 1988;91:493
Human physiologically based pharmacokinetic model for ACE inhibitors: ram. and ramiprilat.
Levitt et al.
BMC Clin. Pharmacol., 2006;6:1
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