Ranolazine dihydrochloride

Catalog # Availability Size / Price Qty
Ranolazine dihydrochloride | CAS No. 95635-56-6 | Dehydrogenase Activators
1 Image
Description: Antianginal, activates pyruvate dehydrogenase
Alternative Names: RS 43285

Chemical Name: N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews (2)

Biological Activity

Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

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Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ranolazine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Ranolazine dihydrochloride include:

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Reversal of HOCl-LDL induced arrhythmia by ranolazine superfusion
By Chintan Koyani on 10/22/2018
Application: Species: Other

Guinea pig ventricular cardiomyocytes were treated (12-16 h) with HOCl-LDL (250 µg/ml). Cells were patched and stimulated at a frequency of 1 Hz. Representative action potentials (shown in Image) recorded in the same cell are shown before (A) and after (B) superfusion with Ranolazine (10 µM, 5 min). For comparative purpose representative APs of a control cardiomyocyte are shown (C).

Ranolazine to block fatty acid oxidation
By Anonymous on 01/30/2018
Application: Species: Mouse

Application of Ranolazine on acute brain slices to verify for fatty acid oxidation involvement in studied process. It had the same effect as etomoxir (CPT1 blocker), as expected per hypothesis.

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