Chemical Name: N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride
Biological ActivityRanolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat.
Zacharowski et al.
Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium.
Shryock and Belardinelli
Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.
Wang et al.
Citations for Ranolazine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ranolazine dihydrochloride include:
3 Citations: Showing 1 - 3
Effects of UK 68798 and RS 43285 on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.
Authors: Carstensen Et al.
J Cardiovasc Electrophysiol 2019;30:596
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons.
Authors: Park Et al.
J Neurophysiol 2013;109:1378
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