Ranolazine dihydrochloride

Tocris Bioscience | Catalog # 3118

Antianginal, activates pyruvate dehydrogenase
Tocris Bioscience

Key Product Details

Description

Antianginal, activates pyruvate dehydrogenase

Alternative Names

RS 43285
View all Dehydrogenase Activators »

Product Description

Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.

Product Specifications for Ranolazine dihydrochloride

Molecular Weight

500.46

Formula

C24H33N3O4.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

CAS Number

95635-56-6

PubChem ID

71279

InChI Key

RJNSNFZXAZXOFX-UHFFFAOYSA-N

SMILES

COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.05 100
DMSO 50.05 100

Preparing Stock Solutions for Ranolazine dihydrochloride

The following data is based on the product molecular weight 500.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.00 mL 9.99 mL 19.98 mL
5 mM 0.40 mL 2.00 mL 4.00 mL
10 mM 0.20 mL 1.00 mL 2.00 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for Ranolazine dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ranolazine dihydrochloride

For research use only

Related Research Areas

Redox Enzymes

Citations for Ranolazine dihydrochloride

Customer Reviews for Ranolazine dihydrochloride (2)

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  • Reversal of HOCl-LDL induced arrhythmia by ranolazine superfusion
    Name: Chintan Koyani
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/22/2018
    Guinea pig ventricular cardiomyocytes were treated (12-16 h) with HOCl-LDL (250 µg/ml). Cells were patched and stimulated at a frequency of 1 Hz. Representative action potentials (shown in Image) recorded in the same cell are shown before (A) and after (B) superfusion with Ranolazine (10 µM, 5 min). For comparative purpose representative APs of a control cardiomyocyte are shown (C).
    Ranolazine dihydrochloride 3118
  • Ranolazine to block fatty acid oxidation
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Brain slice
    Verified Customer | Posted 01/30/2018
    Application of Ranolazine on acute brain slices to verify for fatty acid oxidation involvement in studied process. It had the same effect as etomoxir (CPT1 blocker), as expected per hypothesis.

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