Rec 15/2615 dihydrochloride
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[2-methoxy-6-(1-methylethyl)phenoxy]acetyl]piperazine dihydrochloride
Biological ActivityRec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries.
Morton et al.
Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II.
Testa et al.
Ligand design for α1 adrenoceptor subtype selective antagonist.
Bremner et al.
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