Catalog Number: 3284
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[2-methoxy-6-(1-methylethyl)phenoxy]acetyl]piperazine dihydrochloride
Biological Activity
Selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).
Technical Data
  • M.Wt:
    568.49
  • Formula:
    C26H33N5O5.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    173059-17-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries.
    Morton et al.
    Br.J.Pharmacol., 2007;150:112
  2. Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II.
    Testa et al.
    J.Pharmacol.Exp.Ther., 1997;281:1284
  3. Ligand design for α1 adrenoceptor subtype selective antagonist.
    Bremner et al.
    Bioorg.Med.Chem., 2000;8:201

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