MINDY-2/FAM63B is a member of a newly characterized cysteine protease family of deubiquitinases ("DUBs"). In humans, the MINDY (MIU containing novel DUB family) family has at least four members, with an additional three being MINDY-1/FAM63A, MINDY-3/FAM188A and MINDY-4/FAM188B. The catalytic domain of MINDY DUBs adopts a conformation that is distinct from other known DUB classes, and these enzymes are highly selective at cleaving K48-linked polyubiquitin chains. With a predicted molecular weight of 67 kDa, human MINDY-2 is 82% identical to both its murine and rat orthologs. This recombinant protein is untagged.
Recombinant Human MINDY2/FAM63B Protein, CF
R&D Systems | Catalog # E-620
Discontinued Product
E-620 has been discontinued.
View all MINDY2 products.
Key Product Details
Source
E. coli
Accession Number
Applications
Bioactivity
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Product Specifications
Source
E. coli-derived human MINDY2 protein
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Predicted Molecular Mass
67 kDa
SDS-PAGE
Activity
Recombinant Human MINDY-2 is a Ubiquitin-specific deconjugating enzyme that cleaves K48-linked poly-Ubiquitin chains.
Formulation, Preparation, and Storage
E-620
| Formulation | X mg/ml (X μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 10% (v/v) Glycerol, 1 mM TCEP |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: MINDY2
References
- Abdul-Rehman S.A. et al. (2016) Mol. Cell 63: 146
- Kristariyanto Y.A. et al. (2017) EMBO Reports DOI 10.15252/embr.201643205
Long Name
Ubiquitin Carboxyl-Terminal Hydrolase MINDY-2
Alternate Names
FAM63B, MINDY-2
Gene Symbol
MINDY2
UniProt
Additional MINDY2 Products
Product Documents for Recombinant Human MINDY2/FAM63B Protein, CF
Certificate of Analysis
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Product Specific Notices for Recombinant Human MINDY2/FAM63B Protein, CF
For research use only
Related Research Areas
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