Histone H2A deubiquitinase MYSM1 is a specialized metalloprotease with a predicted molecular weight of 95 kDa. MYSM1 is a member of the peptidase M67A family and the human protein shares 79% amino acid sequence identity with its mouse ortholog. MYSM1 has been reported to function within a large chromatin remodeling complex, containing itself, PCAF, RBM10, TRIP5, and possibly other proteins. Biologically speaking, MYSM1 plays roles in hematopoiesis and lymphocyte differentiation, stem cell maintenance, and innate immunity.
Discontinued Product
E-598 has been discontinued.
View all MYSM1 products.
Key Product Details
Source
Sf 21 (baculovirus)
Accession Number
Applications
Bioactivity
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Product Specifications
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human MYSM1 protein
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Predicted Molecular Mass
95 kDa
Activity
Reaction conditions will need to be optimized for each specific application. We recommend an initial recombinant human MYSM1 concentration of 20-100 nM when using Ubiquitin-AMC or Ubiquitin-Rh110 substrates (U-550, U-555)
Formulation, Preparation, and Storage
E-598
| Formulation | X mg/ml (X μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 10% (v/v) Glycerol, 2 mM TCEP |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: MYSM1
References
-
Belle J.I., et al. (2016) Cell Death Differ. 2016 doi: 10.1038/cdd.2015.140.
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Le Guen T., et al. (2015) J Allergy Clin. Immunol. 136: 1619
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Panda S, Nilsson J.A., Gekara N.O. (2015) Immunity 43: 647
- Zhu P., et al. (2007) Mol. Cell 27: 609
Long Name
Myb-Like, SWIRM And MPN Domains 1
Alternate Names
2A-DUB, Histone H2A Deubiquitinase MYSM1
Gene Symbol
MYSM1
UniProt
Additional MYSM1 Products
Product Documents for Recombinant Human MYSM1 Protein, CF
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Recombinant Human MYSM1 Protein, CF
For research use only
Related Research Areas
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