Recombinant Human SOCS-3 Protein, CF

Recombinant Human SOCS-3 Protein, CF Summary

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: SOCS-3

The Suppressor of Cytokine Signaling (SOCS) protein family consists of 8 members including SOCS1-SOCS7, and CIS (cytokine-inducible SH2-containing protein).  SOCS proteins are a component of the negative feedback system that attenuates cytokine signaling pathways, acting principally by inhibiting the activation of JAK/STAT proteins.  Containing 95% identity with its rat and mouse orthologs, human SOCS3 is a 225 amino acid protein containing an N-terminal kinase inhibitory region, a central SH2 domain, and a C-terminal SOCS domain.  The SOCS domain mediates association of SOCS3 with the Elongin B/C adaptor complex of a CUL2/CUL5 ECS (Elongin BC-CUL2/5-SOCS-box) E3 Ubiquitin Ligase.  SOCS3 is the probable substrate recognition component of such ligases and may play a role in the ubiquitination of proteins including IL6 Receptor beta subunit (gp130), Insulin Receptor, Erythropoietin Receptor, leptin receptors and others.

Related Research Areas

• Diabetes
• Macrophage Activation Markers
• Microglia Activation Markers
• Negative Regulators of the Jak/STAT Pathway
• Stem Cell Transcription Factor Regulators
• Transcriptional Co-Repressors