Chemical Name: 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
Biological ActivityN-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.
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Chemical inhibition of NAT10 corrects defects of laminopathic cells.
Larrieu et al.
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