Catalog Number: 0916
Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride
Biological Activity
Dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo effects of remoxipride and aromatic ring metabolites in the rat.
    Ahlenius et al.
    J.Pharmacol.Exp.Ther., 1997;283:1356
  2. Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors.
    Mohell et al.
    Eur.J.Pharmacol., 1993;238:121
  3. Development of a new antipsychotic remoxipride.
    Acta Psychiatr.Scand.Suppl., 1990;358:1
  4. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
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