Remoxipride hydrochloride

Catalog # Availability Size / Price Qty
Remoxipride hydrochloride | CAS No. 73220-03-8 | Non-selective Dopamine Receptor Antagonists
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Description: Selective D2-like antagonist

Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride

Product Details
Citations (1)
Supplemental Products

Biological Activity

Remoxipride hydrochloride is a dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In vivo effects of remoxipride and aromatic ring metabolites in the rat.
    Ahlenius et al.
    J.Pharmacol.Exp.Ther., 1997;283:1356
  2. Binding characteristics of remoxipride and its metabolites to DA D2 and D3 receptors.
    Mohell et al.
    Eur.J.Pharmacol., 1993;238:121
  3. Development of a new antipsychotic remoxipride.
    Acta Psychiatr.Scand.Suppl., 1990;358:1
  4. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264

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Citation for Remoxipride hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Remoxipride hydrochloride include:

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