Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Biological ActivityAntibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Rifampin: mechanisms of action and resistance.
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
Moore et al.
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Artsimovitch et al.
Pregnane X receptor is SUMOylated to repress the inflammatory response.
Hu et al.
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In our lab rifampicin resisistance in E.coli cells was studied.To assess the level of antibiotic resistance, the minimum inhibitory concentration (MICs) of rifampicin in the non-mutated strain and mutated strain were compared.