Catalog Number: 4121
Alternate Names: Rifampin
Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Biological Activity
Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).
Technical Data
  • M.Wt:
    822.94
  • Formula:
    C43H58N4O12
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    13292-46-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rifampin: mechanisms of action and resistance.
    Wehrli
    Rev.Infect.Dis., 1983;5:S407
  2. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
    Moore et al.
    J.Biol.Chem., 2000;275:15122
  3. Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
    Artsimovitch et al.
    Cell, 2005;122:351
  4. Pregnane X receptor is SUMOylated to repress the inflammatory response.
    Hu et al.
    J.Pharmacol.Exp.Ther., 2010;335:342

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