Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).
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All Tocris products are intended for laboratory research use only.
Rifampin: mechanisms of action and resistance.
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
Moore et al.
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Artsimovitch et al.
Pregnane X receptor is SUMOylated to repress the inflammatory response.
Hu et al.