Ro 04-6790

Name: Ro 04-6790
Brand: Tocris Bioscience
SKU: 2911
Price: 153 USD

Catalog #: 2911 Datasheet / COA / SDS

Discontinued Product

2911 has been discontinued.

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Ro 04-6790 | CAS No. 202466-68-0 | 5-HT6 Receptor Antagonists

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Description: Potent and selective 5-HT6 antagonist

Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ro 04-6790 is a potent and selective 5-HT₆ receptor antagonist (pK_i values are 7.26 and 7.35 at rat and human 5-HT₆ receptors respectively). Displays no affinity at a range of other receptors (IC₅₀ > 10 μM). Induces stretching behavior in rats in vivo.

Technical Data

M.Wt:

308.36

Formula:

C₁₂H₁₆N₆O₂S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

202466-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT₆ receptors.
Sleight et al.
Br.J.Pharmacol., 1998;124:556
Investigation of stretching behaviour induced by the selective 5-HT₆ receptor antagonist, Ro 04-6790, in rats.
Bentley et al.
Br.J.Pharmacol., 1999;126:1537
An update on the role of the 5-hydroxytryptamine₆ receptor in cognitive function.
Fone
Neuropharmacology, 2008;55:1015

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