Catalog Number: 2911
Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
Biological Activity
Potent and selective 5-HT6 receptor antagonist (pKi values are 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Displays no affinity at a range of other receptors (IC50 > 10 μM). Induces stretching behavior in rats in vivo.
Technical Data
  • M.Wt:
    308.36
  • Formula:
    C12H16N6O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    202466-68-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT6 receptors.
    Sleight et al.
    Br.J.Pharmacol., 1998;124:556
  2. Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats.
    Bentley et al.
    Br.J.Pharmacol., 1999;126:1537
  3. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function.
    Fone
    Neuropharmacology, 2008;55:1015

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