Potent and selective 5-HT6
receptor antagonist (pKi
values are 7.26 and 7.35 at rat and human 5-HT6
receptors respectively). Displays no affinity at a range of other receptors (IC50
> 10 μ
M). Induces stretching behavior in rats in vivo
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All Tocris products are intended for laboratory research use only.
Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT6 receptors.
Sleight et al.
Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats.
Bentley et al.
An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function.