Positive allosteric modulator of mGlu1
receptors. Potentiates glutamate-induced calcium release (EC50
= 60.1 nM at rat mGluR1a). Displays no activity at human mGlu1
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A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat et al.
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Knoflach et al.