Ro 67-7476

Key Product Details

Product Description

Ro 67-7476 is a positive allosteric modulator of mGlu₁ receptors. Potentiates glutamate-induced calcium release (EC₅₀ = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu₁ receptors.

Product Specifications for Ro 67-7476

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ro 67-7476

The following data is based on the product molecular weight 319.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.65 mL	31.31 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Knoflach Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 2001 PMID: 11606768
• Hemstapat A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 2006 PMID: 16645124

Product Documents for Ro 67-7476