Chemical Name: (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Biological ActivityRo 67-7476 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu1 receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat et al.
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Knoflach et al.
Citation for Ro 67-7476
The citations listed below are publications that use Tocris products. Selected citations for Ro 67-7476 include:
1 Citation: Showing 1 - 1
SHANK3 controls maturation of social reward circuits in the VTA.
Authors: Bariselli Et al.
Nat Neurosci 2016;19:926
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