Ro 8-4304 hydrochloride

Catalog # Availability Size / Price Qty
3343/10
3343/50
Ro 8-4304 hydrochloride | CAS No. 1312991-77-7 | NMDA Receptor Antagonists
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Description: GluN2B-selective NMDA antagonist

Chemical Name: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride

Purity: ≥99%

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Biological Activity

NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for GluN2B (formally NR2B) containing receptors over GluN2A (formally NR2A) containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
406.88
Formula:
C21H23FN2O3.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1312991-77-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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