Catalog Number: 0958
Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Biological Activity
Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones.
    Benveniste and Mayer
    J.Physiol., 1993;464:131
  2. Investigation of the actions and antagonist activity of some polyamine analogues in vivo.
    Doyle and Shaw
    Br.J.Pharmacol., 1998;124:386
  3. Polyamines modulate the neurotoxic effects of NMDA in vivo.
    Munir et al.
    Brain Res., 1993;616:163
  4. Modulation of channel function by polyamines.
    TiPS, 1996;17:22

The citations listed below are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:

7 Citations: Showing 1 - 7
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  1. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.
    Authors: Quintana Et al.
    Proc Natl Acad Sci U S A 2015;593:4373
  2. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    J Neurosci 2015;35:16171
  3. Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors.
    Authors: Soto Et al.
    J Neurosci 2014;34:11673
  4. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    J Physiol 2011;31:12650
  5. Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.
    Authors: Zonouzi Et al.
    Nat Neurosci 2011;14:1430
  6. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.
    Authors: Soto Et al.
    Nat Neurosci 2009;12:277
  7. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.
    Authors: Campioni Et al.
    J Neurosci 2009;101:3192

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