Spermine tetrahydrochloride

Key Product Details

Product Description

Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Product Specifications for Spermine tetrahydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Spermine tetrahydrochloride

The following data is based on the product molecular weight 348.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.36 mL	28.72 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.44 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

• Munir Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 1993 PMID: 8358608
• Doyle and Shaw Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 1998 PMID: 9641557
• Johnson Modulation of channel function by polyamines. TiPS 1996 PMID: 8789355
• Benveniste and Mayer Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 1993 PMID: 8229795

Product Documents for Spermine tetrahydrochloride