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RO 8191

Catalog #: 7375 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7375/10
RO 8191 | CAS No. 691868-88-9 | IFN-alpha/beta R2
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Description: IFNα receptor 2 agonist

Chemical Name: 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine

Purity: ≥98%

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Biological Activity

RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC50 = 0.2 μM). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 μM). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.

Technical Data

M.Wt:
373.22
Formula:
C14H5F6N5O
Solubility:
Soluble to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
691868-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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