Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Biological ActivityDopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Roxindole: psychopharmacological profile of a DA D2 autoreceptor agonist.
Bartoszyk et al.
Actions of roxindole at recombinant human DA D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors.
Newman-Tancredi et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1999;359:447
Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 DA agonist with actions on serotonin systems.
Seyfried et al.
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