Catalog Number: 1220
Chemical Name: (RS)-4-Phosphonophenylglycine
Biological Activity
A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8; anticonvulsant and neuroprotective in vivo. Also available as part of the Group III mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    231.14
  • Formula:
    C8H10NO5P
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Storage:
    Store at RT
  • CAS No:
    120667-15-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.
    Bigge et al.
    J.Med.Chem., 1989;32:1580
  3. (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
    Gasparini et al.
    J.Pharmacol.Exp.Ther., 1999;289:1678
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-PPG include:

1 Citations: Showing 1 - 1

  1. Constitutive activity of metabotropic glutamate receptor 7.
    Authors: Kammermeier
    Neuropharmacology 2015;16:17

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