(RS)-PPG

Catalog # Availability Size / Price Qty
1220/5
1220/25
Cat.No. 1220 - (RS)-PPG | C8H10NO5P | CAS No. 120667-15-4
1 Image
Description: Potent and selective mGlu8 agonist

Chemical Name: (RS)-4-Phosphonophenylglycine

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8; anticonvulsant and neuroprotective in vivo. Also available as part of the Group III mGlu Receptor Tocriset™.

Technical Data

M.Wt:
231.14
Formula:
C8H10NO5P
Solubility:
Soluble to 100 mM in 1eq. NaOH
Storage:
Store at RT
CAS No:
120667-15-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II.
    Bruno et al.
    Synthesis, 2010;24:4193
  2. Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.
    Bigge et al.
    J.Med.Chem., 1989;32:1580
  3. (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
    Gasparini et al.
    J.Pharmacol.Exp.Ther., 1999;289:1678
  4. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  5. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  6. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  7. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  8. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  9. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  10. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  11. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  12. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  13. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  14. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  15. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11
  16. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist.
    Flor et al.
    Soc.Neurosci.Abstr., 1998;24:431.11

Product Datasheets

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Citation for (RS)-PPG

The citations listed below are publications that use Tocris products. Selected citations for (RS)-PPG include:

1 Citation: Showing 1 - 1

  1. Constitutive activity of metabotropic glutamate receptor 7.
    Authors: Kammermeier
    Neuropharmacology  2015;16:17

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