Catalog Number: 4989
Chemical Name: 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid
Biological Activity
Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
Technical Data
  • M.Wt:
    358.54
  • Formula:
    C22H30O2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    162520-00-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ras inhibition enhances autophagy, which partially protects cells from death.
    Schmukler et al.
    Oncotarget, 2013;4:142
  2. Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib.
    Faigenbaum et al.
    Oncotarget, 2013;4:316
  3. Dislodgement and accelerated degradation of Ras.
    Haklai et al.
    Biochemistry, 1998;37:1306
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Salirasib include:

1 Citations: Showing 1 - 1

  1. A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation.
    Authors: Lee Et al.
    J Virol 2015;5:10305

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