Salirasib

Catalog # Availability Size / Price Qty
4989/10
4989/50
Salirasib | CAS No. 162520-00-5 | Ras GTPase Inhibitors
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Description: Ras inhibitor; also induces autophagy

Chemical Name: 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.

Technical Data

M.Wt:
358.54
Formula:
C22H30O2S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
162520-00-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Salirasib

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2 Citations: Showing 1 - 2

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Salirasib blocks LPA-mediated COX-2 expression
By Anonymous on 12/13/2018
Application: Species: Human

Human osteosarcoma cells were incubated with 20 μM Salirasib for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Salirasib abolished LPA-induced COX-2 expression.


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