Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
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Ras inhibition enhances autophagy, which partially protects cells from death.
Schmukler et al.
Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib.
Faigenbaum et al.
Dislodgement and accelerated degradation of Ras.
Haklai et al.
The citations listed below are publications that use Tocris products. Selected citations for Salirasib include:
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