Chemical Name: 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid
Biological ActivitySalirasib is an inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Ras inhibition enhances autophagy, which partially protects cells from death.
Schmukler et al.
Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib.
Faigenbaum et al.
Dislodgement and accelerated degradation of Ras.
Haklai et al.
Citations for Salirasib
The citations listed below are publications that use Tocris products. Selected citations for Salirasib include:
2 Citations: Showing 1 - 2
Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?.
Authors: Li Et al.
J Cancer 2018;9:3373
A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation.
Authors: Lee Et al.
J Virol 2015;5:10305
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Human osteosarcoma cells were incubated with 20 μM Salirasib for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Salirasib abolished LPA-induced COX-2 expression.