Catalog Number: 3230
Biological Activity
Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
Technical Data
  • M.Wt:
    975.11
  • Formula:
    C47H66N12O11
  • Sequence:
    XRPPGFSPF

    (Modifications: X = Sar, Phe-9 = D-Phe)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    126959-88-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins.
    Drapeau et al.
    J.Pharmacol.Exp.Ther., 1991;259:997
  2. Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins.
    Drapeau et al.
    J.Pharmacol.Exp.Ther., 1993;266:192
  3. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences.
    Leeb-Lundberg et al.
    Pharmacol.Rev., 2005;57:27

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