Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Name: Sar-[D-Phe 8 ]-des-Arg 9 -Bradykinin
Brand: Tocris Bioscience
SKU: 3230

Tocris Bioscience | Catalog # 3230

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Product Documents

Potent and selective B1 agonist

Discontinued Product

3230 has been discontinued. View all Bradykinin Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective B1 agonist

View all Bradykinin Receptor Agonists »

Product Description

Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin is a potent and selective bradykinin B₁ receptor agonist (EC₅₀ = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Product Specifications for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Molecular Weight

975.11

Formula

C₄₇H₆₆N₁₂O₁₁

Storage

Desiccate at -20°C

CAS Number

126959-88-4

PubChem ID

164234

InChI Key

YIUBSFCQATYQJB-VCMDLEIESA-N

SMILES

[H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Drapeau Development and in vivo evaluation of metabolically resistant antagonists of B₁ receptors for kinins. J.Pharmacol.Exp.Ther. 1993 PMID: 8392550
Leeb-Lundberg International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 2005 PMID: 15734727
Drapeau Hypotensive effects of Lys-des-Arg⁹-Bradykinin and metabolically protected agonists of B¹ receptors for kinins. J.Pharmacol.Exp.Ther. 1991 PMID: 1662280

Product Documents for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Certificate of Analysis

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Product Specific Notices for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

For research use only

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