Biological ActivitySar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
(Modifications: X = Sar, Phe-9 = D-Phe)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences.
Leeb-Lundberg et al.
Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins.
Drapeau et al.
Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins.
Drapeau et al.
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