Chemical Name: (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid
Biological ActivitySB 204990 is an ATP citrate lyase (ACLY) inhibitor; it is a prodrug of SB 201076. SB 204990 inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Suppresses growth of cancer cells showing aerobic glycolysis in vitro and in vivo. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.
Pearce et al.
ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R*,5S*)-ω-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzy
Gribble et al.
Citations for SB 204990
The citations listed below are publications that use Tocris products. Selected citations for SB 204990 include:
4 Citations: Showing 1 - 4
Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic�Epigenetic Cross-Talk
Authors: Greenwood Et al.
Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.
Authors: Namgaladze Et al.
Front Immunol 2018;9:2858
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.
Authors: Chen Et al.
Nat Genet 2018;50:219
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
Authors: Shah Et al.
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SB-204990 were used as an ACLY inhibitor in subconfluent endothelial cells. The images are shown in the publication PubMed ID 29429925.