SB 204990

  ( 1 citations )    
Product Datasheet
Catalog Number:4962
Chemical Name:(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid
Product Details
Citations (1)
Reviews
Biological Activity
ATP citrate lyase (ACLY) inhibitor. Prodrug of SB 201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Orally active in vivo.
Technical Data
  • M.Wt:
    389.27
  • Formula:
    C18H22Cl2O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    154566-12-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 204990 include:

1 Citations: Showing 1 - 1

  1. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
    Authors: Shah Et al.
    Oncotarget  2016;7:43713

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