SB 239063

Catalog # Availability Size / Price Qty
SB 239063 | CAS No. 193551-21-2 | p38 Inhibitors
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Description: Potent, selective p38 MAPK inhibitor; orally active

Chemical Name: trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol

Purity: ≥98%

Product Details
Citations (8)

Biological Activity

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

Technical Data

Soluble to 10 mM in DMSO with gentle warming
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Product Datasheets

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Citations for SB 239063

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8 Citations: Showing 1 - 8


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