SB 239063

Tocris Bioscience | Catalog # 1962

Potent, selective p38 MAPK inhibitor; orally active
Tocris Bioscience

Key Product Details

Description

Potent, selective p38 MAPK inhibitor; orally active
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Product Description

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 239063

Molecular Weight

368.41

Formula

C20H21FN4O2

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol

CAS Number

193551-21-2

PubChem ID

5166

InChI Key

ZQUSFAUAYSEREK-UHFFFAOYSA-N

SMILES

O[C@@H]1CC[C@@H](N2C=NC(C4=CC=C(F)C=C4)=C2C3=CC=NC(OC)=N3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.68 10 with gentle warming

Preparing Stock Solutions for SB 239063

The following data is based on the product molecular weight 368.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.14 mL 135.72 mL 271.44 mL
0.5 mM 5.43 mL 27.14 mL 54.29 mL
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 61 publications citing the usage of this product.

Product Documents for SB 239063

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 239063

For research use only

Customer Reviews for SB 239063 (1)

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  • The role of p38 MAPK signaling in LPA induced pro-inflammatory phenotype in microglia cells
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary murine microglia cells
    Verified Customer | Posted 06/08/2019
    The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of SB239063 (10µM) or SB203580 (10µM). A series of assays were performed. p38 MAPK inhibition totally decreased the expression of 4 pro-inflammatory transcription factors (here presented: pp65). Both inhibitors worked nicely and the results were consistent.
    SB 239063 1962

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