Catalog Number: 1962
Chemical Name: trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
Biological Activity
Potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Technical Data
  • M.Wt:
    368.41
  • Formula:
    C20H21FN4O2
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    193551-21-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.
    Barone et al.
    J.Pharmacol.Exp.Ther., 2001;296:312
  2. The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury.
    Legos et al.
    Eur.J.Pharmacol., 2002;447:37
  3. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.
    Underwood et al.
    J.Pharmacol.Exp.Ther., 2000;293:281
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 239063 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition.
    Authors: Agusti Et al.
    J Mol Neurosci 2014;29:955
  2. Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
    Authors: Potapova Et al.
    Metab Brain Dis 2013;8:e73929
  3. Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells.
    Authors: Ferreira Et al.
    PLoS One 2011;8:169
  4. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity.
    Authors: He and Aizenman
    J Neurochem 2010;114:452

Have you used SB 239063?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information