Biological Activity Potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Soluble to 10 mM in DMSO with gentle warming
Desiccate at +4°C
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For batch specific data refer to the Certificate of Analysis.
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Sold for research purposes under agreement from GlaxoSmithKline
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