SCR7 pyrazine

Catalog # Availability Size / Price Qty
5342/10
5342/50
Cat.No. 5342 - SCR7 pyrazine | C18H12N4OS | CAS No. 14892-97-8
1 Image
Description: Enhances HDR efficiency

Chemical Name: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone

Purity: ≥98%

Product Details
Reviews

Biological Activity

Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).

We have discovered that the commercially available SCR7 material supplied by other vendors does not match the chemical structure that it is being sold under. Through detailed chemical analysis carried out by our Analytical Quality Control experts, we believe that the commercially available SCR7 material, including that used in recent publications to enhance CRISPR efficiency, is in fact an analog of SCR7 that we have named 'SCR7 pyrazine'.

View more information regarding the structure of SCR7.

Technical Data

M.Wt:
332.38
Formula:
C18H12N4OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
14892-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV.
    Greco et al.
    DNA Repair (Amst), 2016;43:18
  2. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
    Chu et al.
    Nat.Biotechnol., 2015;33:543
  3. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.
    Maruyama et al.
    Nat.Biotechnol., 2015;33:538
  4. Synthesis and structure determination of SCR7, a DNA ligase inhibitor
    Greco et al.
    Teterahedron Lett., 2016;57:3204

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SCR7 pyrazine

There are currently no reviews for this product. Be the first to review SCR7 pyrazine and earn rewards!

Have you used SCR7 pyrazine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.