Chemical Name: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
Biological ActivitySCR7 pyrazine enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
We have discovered that the commercially available SCR7 material supplied by other vendors does not match the chemical structure that it is being sold under. Through detailed chemical analysis carried out by our Analytical Quality Control experts, we believe that the commercially available SCR7 material, including that used in recent publications to enhance CRISPR efficiency, is in fact an analog of SCR7 that we have named 'SCR7 pyrazine'.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure determination of SCR7, a DNA ligase inhibitor
Greco et al.
Teterahedron Lett., 2016;57:3204
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.
Maruyama et al.
SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV.
Greco et al.
DNA Repair (Amst), 2016;43:18
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu et al.
Citations for SCR7 pyrazine
The citations listed below are publications that use Tocris products. Selected citations for SCR7 pyrazine include:
2 Citations: Showing 1 - 2
Dynamics and competition of CRISPR-Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing.
Authors: Lei Et al.
Nucleic Acids Res 2021;49:969-985
RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.
Authors: John W Et al.
Cell Host Microbe 2020;28:712-723.e9
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