Chemical Name: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
Biological ActivityScriptaid is a novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
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A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.
Su et al.
Cancer Res., 2000;60:3137
Citations for Scriptaid
The citations listed below are publications that use Tocris products. Selected citations for Scriptaid include:
2 Citations: Showing 1 - 2
Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition.
Br J?Cancer 2018;118(10):1359
HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity.
Authors: Sharma Et al.
J Cell Mol Med 2010;14:2151
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TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot.