Selexipag
Chemical Name: 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide
Purity: ≥98%
Biological Activity
Selexipag is a selective prostacyclin IP1 receptor agonist (Ki values are 260 and 2100 nM and for human and rat IP receptors, and >10 μM for EP1-4, DP, FP, and TP receptors). Prodrug for the active form of MRE 269. Ameliorates vascular endothelial dysfunction and increases femoral skin blood flow in rats. Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.
Kuwano et al.
J.Pharmacol.Exp.Ther., 2007;322:1181 -
A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active fo
Kuwano et al.
J.Pharmacol.Exp.Ther., 2008;326:691 -
Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.
Morrison et al.
J.Pharmacol.Exp.Ther., 2010;335:249
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