SEN 12333

Key Product Details

Product Description

SEN 12333 is a α7 nicotinic acetylcholine receptor (nAChR) agonist (EC₅₀ = 1.6 μM, K_i = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H₃ receptors (IC₅₀ = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC₅₀ = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.

Product Specifications for SEN 12333

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SEN 12333

The following data is based on the product molecular weight 339.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.73 mL	29.46 mL
5 mM	0.59 mL	2.95 mL	5.89 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Beinat Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 2012 PMID: 22410083
• Roncarati Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 2009 PMID: 19223665

Product Documents for SEN 12333