SEN 12333

Catalog # Availability Size / Price Qty
4441/10
4441/50
SEN 12333 | CAS No. 874450-44-9 | Nicotinic (a7) Receptor Agonists
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Description: α7 nAChR agonist; also histamine H3 antagonist
Alternative Names: WAY 317538

Chemical Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide

Purity: ≥99%

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Biological Activity

α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.

Technical Data

M.Wt:
339.43
Formula:
C20H25N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
874450-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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